This is an oldie but a goodie. I ran across my use of KeyTweak last week.
Dell, in their infinite wisdom, remapped the keyboard on their Latitude D-series. This put the Insert key right where the Home key is on ThinkPads. Needless to say, this gave me fits toggling Insert.
KeyTweak will let you remap (or in my case UNmap) any keys. The author has a great manual here.
KeyTweak doesn't have to be installed. I keep a copy on my USB key and run it from there when needed.