I've been using Macrium Reflect for almost 2 years since I built Trump.
Recently LifeHacker ran an article on it and I thought I should talk about how it's been working for me.
It treats the Resilient File System (ReFS) like a fully used GPT volume. With Reflect's compression and differential backups this has been acceptable.
I've been taking a full backup once a year and then differentials about monthly.
I have a 5 TB external drive. I created a TruCrypt volume for almost the entire drive and backup to that volume.
I have a Reflect "schedule" that takes a differential so I just run that manually.
It takes 3-4 hours to create the differential for my 2 TB data drives.
You can mount the differential backup as a virtual drive and drag and drop files for restoring.
Nice. And the price is right. Free.